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KMID : 0351619740150020177
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Kyungpook Medical Journal
1974 Volume.15 No. 2 p.177 ~ p.186
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Effect of Diphenylhydantion on Hematopoiesis
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Abstract
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Diphenylhydantoin was administered to male albino rats in order to study its effect on the hematopeiesis and to evaluate the effect of folic acid on the anemia induced by the drug with the following results.
1. Control rats receiving no medication revealed no significant changes in hemoglobin, absolute neutrophil count and platelet count during a period of four weeks.
2. Rats receiving diphenylhydantoin orally at a dose of 5 mg per kg daily disclosed no significant changes in hemoglobin, absolute neutrophil count and platelet count. Also no appreciable differences were noted in marrow megakaryocyte count, erythroid cell count, myeloid cell count, and erythrccyte ^(59)Fe incorporation as compared with those of the control rats.
3. Rats receiving diphenylhydantoin orally at a dose of 50mg per kg daily for four weeks showed a marked decrease if hemoglobin level whereas no significant alterations were observed in either the absolute neutrophil count or the platelet count. The examination of both erythroid cell count and erythrocyte ^(59)Fe incorporation showed significant changes as compared with those of the control rats, whereas the marrow megakaryocyte count, and the myeloid cell count revealed no significant alterations.
4. Rats receiving concomitantly diphenylhydantoin orally at a dose of 50mg per kg and folic acid intramuscularly at a dose of 0.1mg per kg daily for four weeks revealed that folic acid was not effective in ameliorating the anemia induced by diphenylhydantoin.
5. It is concluded from the aforementioned experimental data that rats receiving the administration of large doses of diphenylhydantoin could develop erythroid aplasia.
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